AlphaSize® Alpha-Glyceryl Phosphoryl Choline (A-GPC) found in Neurogenix is recognized as the "premier" choline donor, especially compared to other forms of choline that offer reduced bio-availability. Therefore, AlphaSize® A-GPC is a very special nutrient that has been shown to significantly increase acetylcholine (AC) levels in the brain.

In fact, AlphaSize® A-GPC is considered to be one of the most effective brain nutrients in the world, and is used widely in clinical settings around the world involving memory.

AlphaSize® A-GPC has interesting utility in "mind-to-muscle" sports nutrition formulations, where it acts to optimize muscular power output, sharpen agility, and also delay mental fatigue. This is due to its action involving motor unit activation of muscle fibers and subsequent muscle contraction, as well as due to its mental sharpness benefits.

Health Benefits

  • Improvement in key brain functions, including memory, concentration, learning, recall, and focus.
  • Promotes formation of acetylcholine (AC), a vital neurotransmitter compound involved in all key brain functions and mental sharpness.
  • Helps speed cell to cell communication through neuromuscular optimization, providing enhanced muscular power output and agility for active and athletic individuals.
  • Physiological production and maintenance of human growth hormone (HGH), the body's master hormone for maintaining youth, vitality, and body composition.


Science Information

AlphaSize® Alpha-Glyceryl Phosphoryl Choline (A-GPC) provides an immediate supply of choline to the bloodstream. Choline is an essential component of all major phospholipids in our bodies. Choline undergoes a process called acetylation, resulting in the formation of acetylcholine, which is one of the most important neurotransmitters in the central nervous system, and responsible for the transmission of communication impulses between neurons.

A-GPC crosses the blood-brain barrier to boost choline levels in the brain, and it is involved in the synthesis and release of acetylcholine (AC). This boost of choline and release of AC significantly stimulates cognitive functioning. When a declining choline level becomes a limiting factor in the synthesis of AC, peak mental and physical performance can be negatively and dramatically affected.

Impaired brain cholinergic neurotransmission plays a key role in many forms of cognitive decline.

A-GPC provides a rapidly absorbed form of choline that has been shown to raise free plasma choline levels faster than other choline precursors. Since A-GPC is incorporated into brain phospholipids within 24 hours following absorption, the beneficial memory enhancing effects are fast and noticeable.

In addition, through sophisticated metabolic processes, choline potentiates the secretion of human growth hormone (HGH), a master hormone that in part regulates basal metabolism and hence body composition.

As we age, the amount of HGH we produce steadily declines. It is well accepted that by age 60, serum HGH levels can often be 1/10th of the HGH levels seen at age 25. Like other hormones critical to the functioning of the body, HGH diminishes with advancing age in similar fashion as many other important hormones.

With this marked decline, aging populations may experience diminished vitality and recovery, losses in muscle mass, increases in fat mass, and disruptive sleep patterns.

AlphaSize® A-GPC is considered to be an effective "GH secretagogue", and therefore has potential to be one of the most significant agents to help maintain healthful body composition, help retain lean muscle mass and strength, help reduce fat mass, and help maintain youthful vigor.

During intense exercise, stress and physical activity, choline becomes a limiting factor in the formation of AC, the motor units primary neurotransmitter, thus diminishing AC release at the neuromuscular junction and negatively affecting peak performance.

REFERENCES
Ceda GP, et al. “Effects of an acetylcholine precursor on GH secretion in elderly subjects”. In: Bercu, BB, Walter, RF, eds. Growth Hormone II: Basic and Clinical Aspects. Springer-Verlag; 1994.
De Jesus Moreno M., “Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetyl-choline precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial”. Clin. Therapeu-tics 2002;25:178-193.
Parnetti L. et al., “Cholinergic precursors in the treatment of cognitive impairment of vascular origin: Ineffective approach-es or need for re-evaluation?” Jour. Neur. Sci., 257 (2007) 264-269.
Ziegenfuss T.N., Landis J., J.E. Hofheins. “Acute Supplementation With Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response To, And Peak Force Production During, Resistance Exercise”. The Center for Applied Health Science Research, Division of Sports Nutrition and Exercise Science, Fairlawn, OH 44333
Presented at The Fifth Annual International Society of Sports Nutrition (ISSN) meeting, June 9, 2008, Las Vegas, NV, and submitted for publication to JISSN.


AlphaSize® Alpha-Glyceryl Phosphoryl Choline (A-GPC) Clinical Reference Studies

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